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1 Introduction Globally, diabetes has emerged as a pressing public health concern, affecting approximately 537 million individuals worldwide, predominantly with type 2 diabetes mellitus (T2DM) (Wang et al., 2018)

However, people who are pregnant, breastfeeding, or have medical conditions (like liver or kidney issues) should consult a doctor before starting.

While GI side effects have been suggested to be involved in mediating the weight-loss effect of GLP-1RAs, analysis of large clinical trial data sets with liraglutide and semaglutide has shown that, while GI side effects may lead to more initial weight loss, they are not the mechanism of weight loss as many patients have weight loss and no side effects (182, 183)

Ongoing follow-up

Variations in the size, shape, and insertion points of the ACL can influence the alignment and density of collagen fibers, affecting the ligaments overall mechanical properties