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GLP-1 directly activates POMC/CART neurons and indirectly inhibits, via GABAergic transmission, the neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, which collectively results in signals that reduce food intake

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Maintaining initial weight loss will realistically require continued access to GLP-1 therapies for most patients, as well as ongoing adjunctive diet, exercise and behavioral modifications.(26) Sustained success necessitates ongoing, comprehensive treatment over the long term, not just short-term fixes