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Interestingly, direct injections of Ex-4 into the gustatory cortex of mice maintained on a high-fat diet reduced intake only when the fat density of the test diet differed from that of the maintenance diet, regardless of whether the shift was from high- to low-fat or low- to high-fat relative to the maintenance diet

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Interestingly, by combining GLP-1 and GIP agonism into a single molecule, the GIP/GLP-1 coagonist has enhanced therapeutic properties to improve glucose tolerance and induce weight loss, which was demonstrated in rodents, non-human primates and humans (Finan et al., 2013)

Born in Switzerland, Thorens completed a doctorate at the University of Geneva and then was a postdoctoral fellow there

10.2337/dc23-S010 13