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Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, et al

In oxalate-stimulated HK-2 cells, iron levels increase, accompanied by the upregulation of ACSL4 and TFR1 expression and the downregulation of GPX4, SLC7A11, and ferritin light chain expression, along with typical ferroptosis-related mitochondrial alterations (275)

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PACSIN2 encodes a lipid-binding protein that interacts with Rac1, the molecular target of thiopurines ( MOCOS, MAT1A, MAT2A , and TYMS , though not directly involved in thiopurine metabolism, have also been implicated in thiopurine resistance because of their TPMT activity-altering action (Karas-Kuzelicki et al., 2010

Ascorbate has also been implicated in auxin catabolism and the synthesis of abscisic acid and gibberellins through its functions with different dioxygenases