Exp Rev Endocrin Metab 2014
In a PCOS contextcharacterized by insulin resistance, oxidative stress, and neutrophil primingthe ability of metformin to reduce NETs may translate into diminished neutrophildriven inflammation, improved ovarian microenvironment, and lower systemic thromboinflammatory risk
These mediators, consistently reported in both serum and follicular fluid of women with PCOS, not only mark the systemic inflammatory tone but also provide critical directional cues that link metabolic stress to innate immune reprogramming [24]
Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men
Given the high population prevalence of PCOS, urgent further studies are needed to understand the complex associations between androgen metabolism, insulin signalling, metabolic risk and malignancy in this patient cohort