exendin-4 tirzepatide Ozempic® (semaglutide) and Mounjaro™ (tirzepatide), a major breakthrough for the treatment of obesity Tirzepatide: A Promising Drug for

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Int J Med Sci 2025

doi: 10.1038/nbt.3557

While it can vary by person, some people may start noticing a decrease in appetite within the first few weeks of starting semaglutide, and for many more people, a more noticeable reduction in appetite occurs around 8 to 12 weeks after starting the medication as the dosage is increased