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Beyond proteasomal targeting, non-canonical ubiquitin modifications, including K63-linked polyubiquitination, regulate signaling, endocytosis, kinase activity, and DNA damage responses, while mono- and multi-ubiquitination influence chromatin dynamics, DNA repair, and subcellular localization (Fig

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Questi effetti combinati supportano applicazioni nella medicina rigenerativa, nella ricerca anti-invecchiamento e negli studi di riparazione cellulare

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Data are lacking from long-term studies to assess whether oral treatment is effective when doses are administered less frequently than daily