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IgE binds to mast cells, triggering the release of histamine and cysteinyl leukotrienes, which contribute to bronchoconstriction, edema, and mucus hypersecretion [26]

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The effects of this drug on pain relief was initially evaluated preclinically in herniated NP animal models and could attenuate NPinduced structural changes of the DRG

Most researchers find that morning dosing produces less sleep disruption than evening dosing

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