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The article says severe constipation requiring medical intervention occurred in fewer than 5 percent of trial participants, with most cases mild to moderate and improving through dietary and lifestyle changes

Contraindications and High-Risk Patient Groups Absolute contraindications to tirzepatide include personal or family history of medullary thyroid carcinoma and multiple endocrine neoplasia syndrome type 2 (MEN2)

The phase 3 clinical trials measured results over 16 months, not 6 weeks

Specifically, we used the following search terms: (diabetes OR diabetes type 2 OR diabetes mellitus type 2 OR non-insulin dependent diabetes OR T2D OR T2DM OR type 2 diabetes) OR (obesity, obese or overweight) AND (tirzepatide) OR LY3298176) AND (randomized controlled trial)

Semaglutide dosage Dosage will vary for each individual