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In the rabbit study, embryo-fetal effects consisting of an increased incidence of minor skeletal abnormalities and variants were observed at maternally toxic doses (150 mg/kg/day) resulting in systemic exposures (based on AUC for oseltamivir carboxylate) 8 times human exposures at the MRHD of TAMIFLU

Oral semaglutide at higher doses studied for weight management produced very similar average weight loss over about 64 weeks