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9,46 In clinical studies, L-carnitine showed a significant effect on modulating the inflammatory mediators C-reactive proteins 47,48 and IL- 6 in hemodialysis patients

In a randomized, double-blind, placebo-controlled trial, daily supplementation with Lactobacillus plantarum ECGC 13110402 for 12 weeks in adults with moderate hypercholesterolemia resulted in a significant reduction in LDL cholesterol and hs-CRP compared to placebo, suggesting a direct benefit of probiotics on cardiovascular risk markers in humans (Costabile et al., 2017)

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We will review the relationships between asthma and diabetes, obesity, and weight loss, followed by a description of the GLP-1 RAs and the data on this class in asthma outcomes

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