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6 Role of Nuclear Factor Erythroid 2-Related Factor 2 in Tumor Angiogenesis Due to excessive ROS generation, by interacting with the Notch/delta-like 4 (Dll4) system, Nrf2 promotes vascular sprouting by reducing the impairment of vascular signal transduction and angiogenesis and regulating the production of tip cells (Wei et al., 2013)

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