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-MSH binding to MC1R results in the activation of adenylyl cyclase, increasing the intracellular levels of cAMP and subsequently upregulating TYR, tyrosinase related protein-1 (TRP-1) and tyrosinase related protein-2 (TRP-2) expression

Studies in skin-related models imply it could contribute to improved structure, thickness, and overall resilience of tissues

doi: 10.1016/j.peptides.2010.09.028

Diagnostic features: Focal, multifocal to diffuse areas of inflammation sometimes with vasculitis in immunodeficient mice

This can be particularly observed when over-recommended dosages are consumed because DSIP enhances slow-wave sleep