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doi: 10.1038/s41569-019-0202-5 374

Unlike TB-500 (Thymosin Beta-4 fragment), which acts primarily via G-actin sequestration and endothelial progenitor cell mobilization, BPC-157 exerts its action via an NO-dependent pathway and VEGFR2 modulation two distinct but potentially complementary mechanisms, which is why research protocols sometimes combine both peptides (synergy documented in animal tendon repair models)

The steward's primary rationale for discontinuing maintenance was the topped-out status

short-term room-temperature exposure during handling is acceptable

For women, this raises additional concerns about exposure during sensitive life stages (e.g., pregnancy, postpartum, perimenopause)