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Today, they are the foundation of what will likely become the most important class of medications in the next decade

Diabetologia (2005) 48:6125

Consequently, maintaining the therapeutic effects of GLP-1R agonism requires a long-term dosing regimen, much like medications used for other chronic conditions, such as statins for cholesterol control, ACE inhibitors and beta-blockers for blood pressure, or warfarin for blood thinning

This is not debatable

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