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Importantly, these adducts were detected also in multiple organs of Rattus norvegicus such as the heart, pancreas, and liver

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If patients have a severe obesity-related complication including but not limited to hypertension, type 2 diabetes, CVD, dyslipidemia and a BMI of 27 mg/kg 2 or greater, then concurrent initiation of weight-loss medication with lifestyle interventions can be considered, according to the guideline

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