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The SURMOUNT-1 trial specifically noted that participants with a BMI of 35 or higher who received the 15mg tirzepatide dose lost an average of 26.5% of their body weight, substantially higher than the overall trial average

Quantitative polymerase chain reaction (PCR) was performed in duplicates using TaqMan gene expression assays on a CFX96 Touch Real-Time PCR machine (Bio-Rad, Tokyo, Japan)

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Methionine (2550mg per injection) acts as the primary methyl donor in hepatic fat metabolism, while methylcobalamin (10002500mcg per injection) functions as a cofactor in the methylation cycle