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Thu0054 Nktr-358, a Novel Il-2 conjugate, stimulates high levels of regulatory T cells in patients with systemic lupus erythematosus
At DripGym, Marcus's initial evaluation began with IGF-1 testing, a comprehensive metabolic panel, a hormone panel, and a thorough review of his medical history
We're trying to make tablet-based small molecules back then, and they were just not drug-like enough
Healthy skin has abundant decorin
Drug class Thiazide diuretic Mechanism of action Inhibits Na/Cl symporter in the distal convoluted tubule of the kidney Excretion of sodium and water blood volume blood pressure excretion of potassium, magnesium excretion of calcium (can help prevent kidney stones) Clinical uses Hypertension (first-line therapy) Edema (heart failure, nephrotic syndrome, cirrhosis) Prevention of calcium kidney stones Pharmacokinetics Well absorbed orally Renally excreted unchanged Not a prodrug Adverse effects Hypokalemia Hyponatremia Hyperuricemia gout Hyperglycemia (mild) Hypotension Hypercalcemia Contraindications / Caution Severe renal impairment Hypersensitivity to sulfonamides Hydrochlorothiazide = Active drug Chlorthalidone = Active drug Metolazone = Active drug Thiazide diuretics work directly
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