These include the very powerful, wealthy, influential and frequently supra-national organizations with vested interests in maintaining the current obesogenic environment, and the nature of the evidence underpinning population-based approaches, which tends to be less persuasive than the randomized controlled trials demonstrating effectiveness of drugs. Despite the huge economic cost of obesity, policymakers appear reluctant to use fiscal or regulatory approaches to address its wider determinants, he added
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However, in another intervention trial with combination therapy (53), the risk of adverse effects was significantly higher in the Se supplementation group, which we speculate may be related to unclear baseline Se levels in the subjects and a narrower safety window during Se treatment
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