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Curr Pharm Biotechnol (2005) 6:3739

Pharmacokinetic Method Development: Validate HPLC and bioassay techniques for biphasic disposition profiling and clearance rate determination PubMed

Bioactive compounds from coptidis rhizoma alleviate pulmonary arterial hypertension by inhibiting pulmonary artery smooth muscle cells' proliferation and migration

We were able to show that the circulating form of DPP4 (sDPP4), which lacks the cytoplasmic domain and the transmembrane region, is cleaved off the membrane of human adipocytes and smooth muscle cells in a process called shedding by the involvement of matrix metalloproteases (MMPs) ( Within the TMD, it could be shown that proline residues play an important role for the translocation of membrane-anchored proteins, such as DPP4