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UVR-induced DNA damage and alterations in the extracellular matrix (ECM) disrupt homeostasis and trigger cellular stress, leading to the activation of inflammatory responses in the skin as shown in Figure 2

Moreover, the brain ventricles contain highly vascularized structures, the choroid plexus, composed of fenestrated blood vessels and epithelia sealed by tight junctions

There are various potential causes of vitamin B12 deficiency besides pernicious anemia, which gastrointestinal surgery long-term use of certain medications, such as proton pump inhibitors genetic intrinsic factor defects dietary deficiency Pernicious anemia requires lifelong treatment

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On the other hand, various chemicals have been shown to be activated into potentially dangerous compounds by these enzymes (Sherratt et al., 1997)