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Meng L, et al

Copper is a required cofactor for lysyl oxidase (connective-tissue crosslinking), for superoxide dismutase (antioxidant defense), and for enzymes that support angiogenesis, so a molecule that delivers copper in a controlled, cell-usable form has a coherent reason to influence tissue remodeling and vascular biology

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In the nucleus, Nrf2 promotes glutathione synthesis and regeneration by binding to antioxidant response elements on DNA and subsequently activating the transcription of antioxidant enzymes