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Se also reduces the incidence of autoimmune thyroiditis and other related conditions, and the reduction of thyroid autoimmune effects is related to the role of GPX and thioredoxin reductase (TrxR) as antioxidant defense systems that scavenge ROS and excess H 2 O 2 produced by thyroid cells during thyroid hormone synthesis, which can lead to thyroid cell necrosis and increased macrophage invasion in severe nutritional Se deficiency ( 6 Antioxidant mechanism of different Se forms in fish In the intensive aquaculture system, cultured fish mainly obtain the selenium from the feed

In cerebral I/R injury, increases in thrombin in neurons activate cPLA2 and promote the release of arachidonic acid, which is esterified by ACSL4 and utilized as a ferroptotic fuel

Red flag signs and symptoms include persistent or worsening pain, bladder or bowel dysfunction, or severe neurological deficits

Statistical analysis Natural log transformation was applied to variables that were not normally distributed where required for the application of statistical tests

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