GPR146 deficiency protects against hypercholesterolemia and atherosclerosis
However, the importance of -fetoprotein in protecting female fetuses from behavioral masculinization and infertility at the hands of maternal estrogens is definitively established by observation of both those end points in female neonates with a null mutation rendering them incapable of -fetoprotein production (15)
Prolonged metabolic stress impairs mitophagy and reduces mitochondrial function, as indicated by decreased oxidative phosphorylation, impaired ATP synthesis, and elevated reactive oxygen species (ROS) generation (22)
Experimental models demonstrate that restoring glutathione normalizes mitochondrial redox status and improves endothelial and cardiovascular function, supporting a causal role for mitochondrial glutathione depletion in cardiovascular aging (17-18)
So in certain populations we've seen a reduction in cardiovascular events, improved lipids and blood pressure profiles, and I'll talk a little bit more about that later on in the episode
