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BPC-157 for Musculoskeletal Injuries: Tendons, Fractures, and Soft Tissue A 2025 systematic review of 36 studies found BPC-157 improved functional, structural, and biomechanical outcomes across muscle, tendon, ligament, and bone injury models while consistently reducing inflammatory cytokines IL-1beta and TNF-alpha

These results indicate that BHBA regulates cellular signaling and multiple histone modifications to cooperatively modulate BDNF, suggesting a wide range of regulatory effects of BHBA in the central nervous system