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Mol Cell Endocrinol (2021) 528:111239

Analogous to the BBB, the BRB has an inner component (iBRB) of retinal endothelial cells and an outer component (oBRB) formed by tight junctions between retinal pigment epithelial (RPE) cells [34]

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Weight requirements are one layer of protection, but they are not a substitute for a full clinical picture, which is part of why understanding appropriate candidacy matters just as much as knowing who should use IV therapy in the first place