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We identify a missense variant in GLP1R that is associated significantly with increased efficacy of GLP1 medications ( P = 2.9 10 10 ), with an additional 0.76 kg of weight loss expected per copy of the effect allele
Ele pertence ao grupo das incretinas, substncias que modulam a liberao de insulina de forma dependente da glicose
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It was conducted at 194 hospitals in 16 countries with 1201 patients assigned to semaglutide 0.5 mg, semaglutide 1 mg, dulaglutide 0.75 mg, or dulaglutide 1.5 mg
Multiple GLP-1R peptide agonists that are used clinically or that have entered clinical trials display differential signalling profiles and different clinical efficacies or side-effect profiles (Graaf et al
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