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Glymphatic Stasis TBI disrupts the polarization of Aquaporin-4 (AQP4) channels, leading to "glymphatic stasis." The brain cannot clear its own waste, leading to the accumulation of toxic proteins (Tau, Amyloid) [7]

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This study provides important drug design ideas for GLP-1RA development and a new example for application of structural biology-based protein design in drug development

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