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It inhibits the NF-B and MAPK signaling pathways by activating the SIRT1 deacetylase, reduces ROS production, and delays chondrocyte apoptosis (48)

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Some evidence suggests GLP-1 might also affect reward pathways in the brain related to food cravings and the pleasure response to eating

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Conclusions In KTRs with T2DM, GLP-1 RAs use was associated with substantial reductions in all-cause mortality, MAKEs, and MACEs compared to nonuse without increasing complications