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Notably, discontinuation is associated with weight regain and partial or complete reversal of improvements in cardiometabolic risk factors, including inflammatory markers, blood pressure, lipid profile, and blood glucose levels

So we tapped experts for clarity

Reuters Fernando Cervantes Jr

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All drugs followed a similar trend in which the calculated circulating concentration of the drug at stead state (C ss ) exhibits significant positive association with body weight loss ( Figure 1D )