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Historical human studies primarily involved carefully controlled intravenous exposure

Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice

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In addition, a number of drugs are being developed that target both the GIP and GLP-1 pathways, and triple-agonists at the glucagon, GIP, and GLP-1 receptors