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The transition from episodic to chronic migraine involves changes in nociceptive thresholds and central sensitization, driven by factors such as high frequency of migraine attacks, overuse of acute medications, obesity, stress, female sex, psychiatric conditions, and low socioeconomic status (34)

Most patients with Parkinsons disease are over 60 years old, but there are cases where it appears at a younger age, known as early-onset PD

The Journal of Clinical Endocrinology and Metabolism, 80 (4), 14291430

Mood Alcohol exaggerates the mood of a person

Its result on aging, below, is the reason the same compound appears in both camps