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Pathogenicity predictions for missense variants were conducted using MutPred2 [35] ( and Missense3D [36] ( For MutPred2 analysis, amino acid sequences in FASTA format were retrieved from NCBI Protein database [37]

Department of Veteran Affairs, including individuals diagnosed with non-alcoholic hepatic steatosis who began treatment with either GLP-1 RAs or DPP4i between October 2005 and September 2021

IGF-1s primary function is to mediate the anabolic effects of the hGH and plays a major role in growth regulation in children