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The evolution from single to triple agonism The trajectory of incretin-based obesity pharmacotherapy shows a clear pattern of increasing complexity and efficacy: First generation (single agonist): Liraglutide (Saxenda) and semaglutide (Wegovy) target GLP-1 only

Forxiga (dapagliflozin): plausible role in the treatment of diabetes-associated neurological disorders

If not, the discussion is moot

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The absence of Treg cells enhanced the activation of resident and invading inflammatory cells (including microglia and T cells) after ischemia, which were the main sources of harmful TNF- and IFN-, respectively