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Mechanisms Beyond Adiposity: The substantial MACE reduction not explained by weight or waist changes points to direct cardiovascular effects, including: Improved endothelial function and vascular health Anti-inflammatory pathways via central GLP-1 receptor signalling Favourable effects on blood pressure and lipid metabolism Possible early adipose tissue metabolic improvements before measurable mass reduction 3

& Ventura, R

MSCs may be sourced from human umbilical cord, adipose tissue, Whartons jelly, or bone marrow

Theriogenology 62 , 468480 (2004)

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