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In addition, mtROS can also directly act on some proteins on the mitochondrial matrix or mitochondrial membrane, and regulate the activity of mitochondrial complex I, complex III, and complex IV through Toll-like receptors, retinoic acid-inducible gene I-like receptors and other signaling pathways, thereby affecting OXPHOS

Fluoroquinolone exposure tends to suppress the TCA cycle and activate the glyoxylate shunt, conserving carbon and reducing ROS while channeling electrons into NADPH/GSH synthesis

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Connected by a disulfide bond (SS), which has been shown to be more stable in water and high temperatures than oxidized glutathione

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