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As a tripeptide composed of glutamate, cysteine, and glycine, it functions as the primary thiol-based redox buffer, neutralizing reactive oxygen species (ROS), supporting Phase II detoxification pathways, and facilitating the excretion of xenobiotics and heavy metals [1] [8]

Hemichannels also contribute to liver damage by facilitating the influx of toxic substances and the loss of essential metabolites

MOTS-C MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene

doi: 10.3389/fncel.2015.00361 104 MakitaNHizukuriYYamashiroKMurakawaMHayashiY