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Indeed, the free NAD + concentration largely varies depending on several factors, including its subcellular compartment

Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels

Published 2018 Oct 23

Comorbidities of self-reported fibromyalgia in United States adults: A cross-sectional study from The National Epidemiological Survey on Alcohol and Related Conditions (NESARC-III)

These findings were interpreted as indicative of a possible correlation rather than a definitive causal relationship, reinforcing the need for further controlled investigations to clarify underlying mechanisms