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Read More: To view or add a comment, sign in Managing Stage 4 Lipedema: The Critical Necessity of Lymphatic Intervention When lipedema progresses to Stage 4, it transitions into Lipo-lymphedemaa complex state where the extensive accumulation of adipose tissue severely compromises the lymphatic system

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Inflammation and insulin resistance frequently affect the liver, a central organ that is crucial to the regulation of energy metabolism (Gustafson & Smith, 2015)