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Therefore, the combined metabolic and functional disruptions in DAAs and reactive astrocytes exacerbate neuronal dysfunction, cellular pathophysiology, and cell death, contributing to progression in CNS pathology

Evidence of liver toxicity may develop in one to four days, although, in severe cases, it may be evident in 12 hours

10.1096/fj.08-111005 54 HaddadY

Additionally, DFO, deferiprone and N-acetylcysteine (NAC) have also been classified as ferroptosis inhibitors due to their targeting of other cellular pathways [92]