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The study was published in Volume 68, Issue 6 of the Endocrine Journal and authored by Dao-Gen Yin, Liang-Liang Ding, Hai-Rong Zhou, Mei Qiu, and Xue-Yan Duan

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Interestingly, despite of the extracellular conformational differences induced by compound 2 and orthosteric agonists, their intracellular architectures underwent a similar reorganization of polar residues that enabled the formation TM6 sharp kink with the help of G protein binding 42,45 , indicative of GLP-1R activation (Fig