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PMC 8614756

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Notably, BCBs are the critical mediator and modulator of TBI pathology progression

Conservative management strategies include: Optimize gastrointestinal function: Address constipation proactively with adequate hydration (individualized to the patient's cardiovascular and renal status), dietary fiber supplementation, and when necessary, osmotic laxatives such as polyethylene glycol

GSH and CG bind at an inter-protomer surface pocket on EV-F3 To determine if GSH binds to the enterovirus capsid, data to 1.8 resolution were collected from crystals of EV-F3 soaked with GSH by automated X-ray cryo-crystallography (Methods and Table 1), yielding high-quality electron density and a reliable model for surface-bound GSH (Fig