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Mitochondria and peroxisomes are two major groups of cellular organelles responsible for the endogenous production of reactive oxygen species

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doi: 10.1016/j.clindermatol.2021.05.010 42 DosedlMJirkovskEMackovKKrmovLKJavorskLPourovJet al

excess GPx1 decreased growth factor stimulated cellular proliferation, and reduced growth factor mediated signal transduction and activation of Akt [16]

Thus, the combination of injury to the parieto-temporal cortex and increased lesion volume, combined with decreased hippocampal volume with age, may explain the observed poor performance in the novel object recognition test by TBI + vehicle (NS) treated rats