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The Bliss synergy score was therefore calculated as follows: In this context, a positive Bliss score means that the observed effect of the combination is lower than what would be anticipated if the drug effects were independent, thereby indicating synergy

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Levocarnitine has isolated case reports of potentiating the anticoagulant effect of warfarin, leading to unexpectedly high INR readings

High-dose oral B12 is not routinely used for pernicious anaemia management in NHS practice

In cases of methotrexate hepatotoxicity, vitamin B12 supplementation counteracts the decrease in vitamin B12 levels and mitigates liver damage [150]