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While vitamin C and E hang out in your bloodstream, glutathione actually gets inside every single cell in your body

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5a), indicating that the NAC effect is related to posttranscriptional modifications

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Loss of neurons associated with glutathione depletion has also been reported in rodents treated with morphine or heroin [13,14,15,16] but the evidence for equivalent depletion in human brains from opioid abusers is mixed, with one group reporting significant depletion [17,18] and another reporting none [19]