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Participants were assigned to receive weekly doses of retatrutide at 1 mg, 4 mg, 8 mg, or 12 mg for 48 weeks, or placebo

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It appears to modulate activity of immune cells called microglia that regulate central nervous system inflammation, potentially beneficial for conditions like multiple sclerosis and other neuroinflammatory disorders

Events such as the accumulation of visceral adipose tissue, increased plasma concentrations of free fatty acids, tissue hypoxia, and sympathetic hyperactivity in individuals with MetS may contribute to the activation of the innate immune response, which compromises cerebral microcirculation and the neurovascular unit, leading to the onset or progression of neurodegenerative diseases

The process is observed either under massive increase of radical species or under physiological ROS flux