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Br J Haematol 1994

Renal function decline as GLP-1 and GIP agonists can cause nausea, diarrhoea and vomiting, this may result in dehydration and associated reduction in renal function

The presence of multiple bioactive lignans with varying physicochemical properties complicates the design of a standardized formulation, making it difficult to achieve consistent pharmacokinetics and predictable therapeutic outcomes