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This triggers broken immune tolerance: Overactivated innate immune cells secrete pro-inflammatory cytokines, CD4 + T cells skew toward pro-inflammatory subsets (T-helper 1 [Th1] cells/Th17), T regulatory cell (Treg) function is impaired, and autoantibodies exacerbate inflammation

doi: 10.1016/j.lfs.2020.117850 423 HaoMLiuYChenPJiangHKuangHY

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