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Nfr2 and antioxidant genes support a protective system that suppresses inflammation and oxidative damage ( The nuclear respiratory factors (Nrf1 and Nrf2) that initiate the transcription of genes linked to mitochondrial biogenesis are co-activated by SIRT1 through the activation and deacetylation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1) ( Gardeniae Fructus reduces TAA-induced liver fibrosis in mice by activating the Nrf2 and AMPK/SIRT1 pathways

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Full text: Barciela, P., Perez-Vazquez, A., & Prieto, M