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Methods: We surveyed preclinical and clinical studies investigating the impact of vitamin D and exercise on neurotrophic signaling (e.g., BDNF, IGF-1), vascular and inflammatory pathways (e.g., VEGF, cytokines), and cognitive or functional outcomes in aging models and older human populations

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Protein interaction network analysis also revealed that the subnetwork mediated by NDUFS1and NDUFV2 in energy metabolism was affected significantly after riboflavin deficiency

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